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Peterman threw five interceptions - more than Taylor had thrown all season - in one half of football while making his first career start. Peterman threw a pick-six on the Bills' first possession and followed that up with another interception on his second possession.

The Bills' decision to bench quarterback Tyrod Taylor in favor of Nathan Peterman did not look like a good one through two quarters, with Peterman throwing four interceptions in his first nine passes and adding a fifth pick later in the game before he was eventually pulled.

Taylor replaced Peterman in the second half and had more success against a Chargers team that was already looking forward to Thursday's game in Dallas.

The Buffalo Bills will be heading all the way out to the west coast to square-off against the Los Angeles Chargers in Week 11.

Rivers passed for 250 yards and Keenan Allen had 12 receptions for 159 yards and two touchdowns for the Chargers (4-6), whose offence capitalized on the extraordinary bounty created by its defence. He also ran for a score in the fourth quarter.

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The Bills responded back in a major way, as running back LeSean McCoy on two plays was responsible for Buffalo's tying touchdown.

Nick Novak's second field goal, a 27-yarder, gave the Chargers a 27-7 cushion midway through the second quarter. The pass hit fullback Pat DiMarco in the hands and went airborne, allowing Toomer to catch it for a rollicking return down the Buffalo sideline.

The move blew up in the Bills' face right away as Peterman threw five interceptions.

Bills: Buffalo played without starting LT Cordy Glenn and WR Jordan Matthews, who sat out with a knee injury. Chargers LT Russell Okung (leg) exited in the second quarter.

Los Angeles coach Anthony Lynn had expressed optimism about Rivers' availability before the 35-year-old veteran cleared the NFL's concussion protocol on Friday.