"I don't think she's going to run", Trump told reporters during an immigration meeting.
Winfrey asked the panel about their response to the #MeToo movement, the president's fitness for office, and the sexual harassment accusations against him during the campaign as well as his comments on Twitter about New York Senator Kirsten Gillibrand and his comment about "sh*thole countries".
Sunday the President accused Winfrey of conducting a one-sided interview on CBS' 60 minutes. "I think that when you have that many people whose opinions you value coming at you, it's worthy of thinking about". I've always felt very secure and confident with myself in knowing what I could do and what I could not.
In 1988, Trump told Oprah he probably would never run, adding: "I think I'd win - I tell you what, I wouldn't go into lose".
All you need to know about Samsung Galaxy S9 and S9+
The S9 Plus' secondary rear camera would be locked at f/2.4 and would be intended more for zoomed or portrait photos. If the rumor is indeed accurate, the Nokia 4 will be more powerful than both the Nokia 5 and Nokia 6 smartphones.
From a SNAP recipient to Trump: Food box is a "terrible idea"
President Trump's budget proposes massive cuts to the program that provides more than 42 million Americans with food stamps. He says SNAP is efficient because it is a "free market model" that lets recipients shop at stores for their benefits.
S. Korea footing big bill to host North Koreans at Olympics
Attention was also lavished on an army of attractive North Korean cheerleaders, which included the dictator's wife, Ri Sol-ju. Mr Pence came face to face with Ms Kim at the opening ceremony of the Winter Olympics , but they did not interact.
Indeed, there was a lot of discussion regarding his temperament, attitude and intelligence, and some unflattering things were said.
Oprah sparked speculation that she might run for office following her rousing speech on equality at January's Golden Globe awards.
"Oprah would be a problem: she'd be their best", the strategist told the publication.
'I saw an Oprah 2020 mug...
"I don't agree that it is okay to tweet the way that he does, getting in a war with North Korea, 'My button's bigger than your button, '" she said.
Trump called out Winfrey for being "insecure".
On Monday, Kevin Ryan, president and CEO of Covenant House, a Catholic charity recognized as the largest privately funded agency in the Americas dedicated to serving homeless youth and ending child trafficking, publicly praised Winfrey for her support to the organization.