Arsenal travelled to the Amex stadium in a hope to revitalise their confidence ahead of their clash against Milan in the Europa League - they didn't.
The recalled Alex Iwobi then played Arsenal into trouble, smashing a clearance straight at Anthony Knockaert, who should have scored after exchanging passes with Pascal Gross. Glenn Murray made it two for Brighton less than twenty minutes later thanks to some truly dire defending by the visitors.
It seems as if the Gunners are breaking records this season, and not ones they'd like to remember; for the first time in 16 years, they have lost four games in a row.
"He started well this season but his performance levels, goalscoring, assists, high pressing, bringing the team with him as number 10, were decreasing step by step", Manchester United manager Jose Mourinho said in November, before allowing Mkhitaryan to leave for Arsenal.
And it was 2-0 after 26 minutes as Arsenal gave away the simplest of goals.
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Shortlisted replacements such as Joachim Low and Leonardo Jardim will need huge investments to turn around the fortunes of the team. Laurent Koscielny's loose pass from the back was recycled to Gross and his inch-perfect delivery was thudded home by Murray, whose downward header skidded under Cech.
Either way, the Czech goalkeeper hit Twitter to accept all responsibility for Arsenal's fifth loss in six matches, saying, "If you want to win a game away of home in the best league in the world your GK can't concede 2 goals like I did today ... it's simply not possible ..."
Sadio Mane's goal in the second half ensured there was no joy for Newcastle manager Rafa Benitez, whose Liverpool team won the UCL in 2005. Granit Xhaka fed the ball into Pierre-Emerick Aubameyang, who cleverly flicked the ball home with the outside of his boot.
Chants of "Wenger Out" swirled around the pitch when the Gunners went 2-0 down amid growing uncertainty over the future of the Frenchman at the Emirates.
Ozil had been quiet in the first half but a powerful run and shot brought a fine save from Mat Ryan before the German's threaded pass nearly let in Aubameyang for his second goal.