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The U.S. president later conferred with French President Emmanuel Macron, and they agreed on the need for a "firm response" to the attack, Macron's office said.

Russian Federation and Syria have invited a probe into the alleged chemical attack on the rebel-held town of Douma after USA president Donald Trump threatened that there would be a "big price to pay".

File image of Syrian president Bashar al-Assad.

The Syrian government denied the allegations, which could not be independently verified. It was also reported that the Syrian Air Defense Force opened fire on the upcoming missiles and intercepted several.

In February, Macron had said "France will strike" in the event of a lethal chemical weapon attack on civilians by government forces in Syria.

Russia's Defense Ministry said two Israeli aircraft targeted the base yesterday, firing eight missiles.

Syrian state media, citing a military source, carried a similar report.

Syrian state TV meanwhile quoted the unnamed military official as saying Israeli F-15 warplanes had fired several missiles while flying over neighboring Lebanon.

Israel has accused Damascus of allowing Iran to set up a complex at the T-4 base to supply arms to its ally, Lebanon's Hezbollah, and in the past its forces have hit convoys and bases of Iranian-backed militias that fight alongside Assad's troops.

"We express our readiness, after the liberation of Douma from militants, to immediately send Russian specialists in radiological, chemical and biological protection for the collection of data, that will confirm the fabricated character of these statements", Yevtushenko said.

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Chiding his stance, Trump, in another tweet said, "If President Obama had crossed his stated Red Line In The Sand, the Syrian disaster would have ended long ago!"

"It's time. We were successful against ISIS", Trump said.

Trump today condemned the "heinous attack" in Syria and said later at a Cabinet meeting that he would "forcefully" respond.

The toll is likely to rise, said the Union of Medical Care Organizations (UOSSM), a group of worldwide aid agencies. However gaining access to samples on the ground would be hard.

Syrian opposition activists and local rescuers said on Sunday that the suspected attack from the previous day against the last remaining foothold of the rebels in the eastern suburbs of Damascus killed at least 40 people. The US Department of Defence, however, denied government forces had launched any chemical attack.

Worldwide condemnation grew over a suspected poison gas attack in a rebel-held town near Damascus said to have been carried out by the Syrian government, while Syria and its main ally, Russia, blamed Israel for airstrikes on a Syrian air base that reportedly killed 14 people, including four Iranians. The gas attack was blamed on Assad. SANA said the missile attack resulted in a number of casualties, but provided no specific figures.

Haley accused Russian Federation of protecting Syria at the United Nations while Moscow's military advisers in Damascus are helping Assad wage a "starve or surrender campaign" against Syrian civilians that includes the use of chemical weapons.

And in 2017, the Syrian government used sarin once again, this time against civilians in the town of Khan Sheikhoun.

For weeks, the remnant rebel holdout east of Damascus has faced an offensive by Syrian government forces, prompting moves to evacuate civilians, although Jaish al-Islam rebels have not confirmed such a deal.