More than 70 women have accused the co-founder of the Miramax film studio and Weinstein Co of sexual misconduct, including rape, with some allegations dating back decades.
His next court appearance is July 30, when he'll likely learn if he's been indicted. The office of Attorney Benjamin Brafman, who is representing Weinstein, said that he would not comment on reports of Weinstein's surrender. He said his client entered a plea of not guilty, and will attempt to have the charges dismissed.
She also tweeted, "We got you, Harvey Weinstein, we got you".
A statement from the NYPD - which has worked with the DA office on the case - also thanked "these courageous survivors for their courage to come forward and seek justice".
The charges follow a flood of accusations against Weinstein that led women around the world to come forward with accounts of being sexually harassed by powerful men.
She told The New Yorker in a story published in October that Weinstein forced her to perform oral sex during a daytime meeting at his New York office in 2004, the summer before her senior year at Middlebury College.
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Police in Los Angeles and London have also been investigating reports filed against Weinstein by multiple women.
These are the first criminal charges against Mr Weinstein, who already faces a raft of civil lawsuits. Women and a few men have publicly accused powerful men in business, government and entertainment of unwanted sexual behavior or sexual abuse.
Weinstein's rep released a statement following the publication of the New Yorker expose, denying the accusations against him. The 66-year-old Oscar victor was accused of sexual misconduct in investigative reports published by The New York Times and The New Yorker in October 2017.
Rose McGowan, one of Weinstein's most outspoken accusers, told The Hollywood Reporter Friday's arrest brings victims "one step closer to justice". His attorney says Weinstein maintains that all sexual acts were "consensual".
The rape charge relates to a woman who was not identified.
"The NYPD thanks these fearless survivors for their courage to come forward and seek justice", the NYPD said in a statement. "Had he been held accountable years ago, there would be fewer victims of his sex crimes", Harrison said. According to the New York Police Department, these charges are in relation to incidents involving two women in New York.
McGowan, who was among the first to come out and accuse Weinstein of misconduct, appeared on Megyn Kelly Today, where she described seeing the predator in handcuffs for first time.