The killing of Dawn Sturgess, a mother of three, will increase pressure on President Putin after Sajid Javid, the home secretary, accused the Kremlin of using Britain as a dumping ground for poison.
Dawn Sturgess died Sunday evening at the hospital where she'd been critically ill since coming into contact with the toxin on June 30, according to the BBC.
She had been hospitalised after falling ill on June 30, along with a 45-year-old man, in Amesbury, Wiltshire.
Composite photo of 44-year-old Dawn (L) Sturgess and 45-year-old Charlie Rowley.
Test samples from Sturgess and Rowley show they were exposed to Novichok "after touching a contaminated item with their hands", police said.
A woman has died in hospital more than a week after she was exposed to novichok in the first death from the nerve agent attack on Britain that the government has attributed to Russian Federation.
The Skripal attack took place in the city of Salisbury, just a few kilometres away from the site of the Amesbury poisoning incident.
Police have announced that they've launched a full homicide investigation.
The British defence lab determined earlier that Novichok, a type of nerve agent developed by the Soviet Union during the Cold War, was used on Sergei Skripal, a former Russian intelligence officer once convicted in his homeland of spying for Britain.
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Russia, which is now hosting the soccer World Cup, has denied any involvement in the Skripal case and suggested the British security services had carried out the attack to stoke anti-Moscow hysteria.
It is with great sadness that we have learned of the tragic death of 44 year old Dawn Sturgess, as reported by AC Neil Basu and the Prime Minister. Skripal was discharged from the hospital in May and his daughter was released in April.
Salisbury District Hospital treated Sturgess and Rowley.
"We are not in a position to say whether the nerve agent was from the same batch that the Skripals were exposed to". "Police and security officials are working urgently to establish the facts of this incident, which is now being investigated as a murder".
The new poisoning has frightened some residents who thought an extensive cleanup had removed the threat of any further Novichok exposure.
Police said Ms Sturgess' family had been notified and were receiving support.
Sergei Skripal and his daughter, Yulia, almost died of exposure to Novichok left on the front doorstep of Sergei's home in March.
The two Britons had been taken ill last Saturday.