Saturday's vote is likely to come down to just a handful of undecided senators.
Republicans appear to have the votes to confirm Kavanaugh, but the confirmation will come down to perhaps one or two key votes.
Republican Senator Lisa Murkowski, another swing vote, voted no in the procedural voting.
Senate Republicans, except for Lisa Murkowski, have stood by him in a move that could resonate, particularly with women voters, in the November 6 elections to determine control of the Senate and House of Representatives.
The closest confirmation votes for a Supreme Court nominee were decided by a single vote.
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In another development, more than 2,400 law professors had signed on a letter sent to the Senate on Thursday, saying Kavanaugh lacks judicial temperament and thus is disqualified from sitting on the nation's highest court, according to a report of The Washington Post. She said that the process had not been "fair" to Kavanaugh, but that ultimately it had become about something "bigger than a nominee".
The FBI investigated the allegations this week by Dr. Christine Blasey Ford that Judge Kavanaugh groped her and attempted to rape her when he was drunk at a high school party. Rob Portman of OH came over to Murkowski and took her hand, shaking it. Texas Sen.
The White House, McConnell said, "took some grief for a decision they didn't make" - referring to the scope of the FBI's background investigation into allegations that Kavanaugh sexually assaulted two women in separate instances decades ago.
A final vote on whether Judge Kavanaugh will join the nine-member panel could take place as soon as Saturday.
Republicans have a 51-49 majority in the Senate.
Susan Collins, a Maine Republican, said that sexual assault allegations against Kavanaugh weren't strong enough to persuade her to vote no. "This is what I've been wrestling with", Murowski said.
I believe is is a good man.